Commentary(McDermott/Hudes)—Testicular Cancer: Maintaining the High Cure Rate
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چکیده
Dr. Raghavan is to be commended for a concise and comprehensive overview of the management of germ cell tumors. As he suggests, given the demographics of this relatively uncommon disease and the high cure rate that can be achieved with proper treatment and follow-up, it behooves us to maintain these excellent results, even while striving to reduce the toxicity of treatment. We will highlight a few additional points to complement this superb review.
منابع مشابه
Treatment-related Cardiovascular Toxicity in Long-term Survivors of Testicular Cancer
BACKGROUNDS Testicular cancer is the most common malignancy in young men. Considering increasing incidence, exceptionally high cure rate, as well as long life expectancy, assessment of long term toxicity in testicular cancer survivors is of great importance. In the last decades a major effort has been made in order to reduce toxicity of treatment, while maintaining its high effectiveness. CON...
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Despite the overall cure rate now in excess of 90%, innovation in management of germ cell tumors continues. The report that 80% of patients with extragonadal germ cell tumors have either carcinoma in situ or atrophic tubules as evidence of tumor rejection emphasizes the need to investigate the testis in patients with undiagnosed primary cancer because even today treatment delay is worsening pro...
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The management of germ cell tumors has advanced dramatically, with cure rates approaching 90% to 95%. Treatment of stage I/A seminomas generally includes orchiectomy and adjuvant radiotherapy. Treatment of stage I/A nonseminomatous germ cell tumors involves orchiectomy followed by retroperitoneal lymph node dissection or active surveillance. One of the major advances has been the introduction o...
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Our initial studies with cisplatin + vinblastine + bleomycin began 27 years ago in 1974, changing the cure rate for disseminated disease from 5 to 60%. Subsequently, through random prospective clinical trials, we have modified the treatment regimen to reduce both the duration and dosages of the chemotherapy drugs. Cisplatin + etoposide was first used at Indiana University as salvage chemotherap...
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تاریخ انتشار 2017